Transplantation of Skin Components during Chemical Carcinogenesis with 20-Methylcholanthrene
نویسندگان
چکیده
منابع مشابه
Skin Carcinogenesis by a Single Application of 20-Methylcholanthrene*
In our study of the early stages of carcinogenesis (2, 3), it was found that a single external application of the carcinogen to the skin with one brush stroke was sufficient to elicit, after 3 or 4 weeks and in a considerable fraction of the animals, an epithelial hyperplasia sufficiently advanced to merit the term "precancerous." Most of the animals used in that investigation were killed withi...
متن کاملThe Early Stages of Carcinogenesis by 20- Methylcholanthrene in the Skin of the Mouse
Reports of Experimental Research CARCINOGENIC COMPOUNDS ALLSOPP, C. B. [Strangeways Lab. and Univ. Dept. of Colloid Science, Cambridge, England] A WATER-SOLUBLE CARCINOGEN DERIVED FROM 8:4-BENZPYRENE. Nature, London, 150:548-549. 1942. A solution of 3,4-benzpyrene in benzene and cyclohexane was irradiated in almost pure monochromatic ultraviolet light of 2,537 A; the product, soluble in M/Ioo N...
متن کاملSensitization of Skin by Carcinogenically Inactive Methylcholanthrene to Subsequent Carcinogenesis*
The fact described in the preceding paper (9), tl'tat methylcholanthrene dissolved in anhydrous lanolin fails to produce a carcinogenic effect and does not even induce early skin changes such as epilation, epidermal hyperplasia, destruction of sebaceous glands, and diminution in the calcium and iron content of the epidermis, has been established in 4 experimental series comprising 312 mice. Sin...
متن کاملA reinvestigation of epidermal transplantation during chemical carcinogenesis.
The possibility that epidermis which has never been exposed to carcinogen can give rise to carcinomas if it is transplanted onto carcinogen-treated dermis was raised by the experiment reported by Billingham, Orr, and Woodhouse in 1951. They treated mice topically with methylcholanthrene for 12 weeks, left them untreated for 2 weeks to allow the methylcholanthrene to disappear, and then transpla...
متن کاملSkin nucleic acid phosphorus metabolism of DBA-1J mice during implanted tumor development and methylcholanthrene carcinogenesis.
Implanted tumors and methylcholanthrene Carcinogenesis increase the turnover of phosphorus in the total nucleic acids of histologically normal DBA/1J mouse skin. As the implanted tumors progress for 6 days, the turnover rate of nucleic acid phosphorus in the histologically normal skin increases to 4 times that of control skin from normal DBA/1J mice. At this same time, 68% of the histologically...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1951
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1951.48